Profile Detail

Claudiu  Schirda, PhD

Assistant Professor

Interest (in 3 to 10 words):

Medical / Graduate School University of Pittsburgh, PhD, Physics
University of Pittsburgh, MSc, Physics
Clinical / Post-doctoral Fellowship
Current International Society of Magnetic Resonance in Medicine (2002-present)
American Academy of Neurology (2008-present)
& Programs
Clinical Interest Multiple Sclerosis
Hepatic steatosis
Research Interest - Fast brain 1H and 31P MR Spectroscopic Imaging (MRSI) and reliable quantification using LC Model

- Leg muscle functional P31 spectroscopic imaging

- Liver 1H spectroscopic imaging and fat/water ratio quantification

- Robust Glx and GABA MRS measurements and quantification

- High-Resolution Phase-Contrast multi-echo Susceptibility Weighted Imaging (SWI) using high density phase array coils

- Optimization of sequences for UHF (ultra high field, >=7T) imaging

Selected Publications   1. Schirda, C., Tanase, C. and Boada F, Rosette Spectroscopic Imaging: Optimal Parameters for Artifact-free, High Sensitivity Spectroscopic Imaging Journal of Magnetic Resonance Imaging, 2009 Jun;29(6):1375-85., PMID 19472411

2. Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojanacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, and Zivadinov R: The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics. Funct Neurol. 2009 Jul-Sep ;24(3):133-8. PMID 20018140

3. Zivadinov R, Schirda C, Dwyer MG, Haacke ME, Weinstock-Guttman B, Menegatti E, Heininen-Brown M, Magnano C, Malagoni AM, Wack DS, Hojnacki D, Kennedy C, Carl E, Bergsland N, Hussein S, Poloni G, Bartolomei I, Salvi F, and Zamboni P. Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study. Int Angiol. 2010 Apr;29(2):158-75. PMID 20351672.

4. Zivadinov R, Lopez-Soriano A, Weinstock-Guttman B, Schirda CV, Magnano CR, Dolic K, Kennedy CL, Brooks CL, Reuther JA, Hunt K, Andrews M, Dwyer MG and Hojnacki DW. Use of MR venography for characterization of the extracranial venous system in patients with multiple sclerosis and healthy control subjects. Radiology. 2011 Feb;258(2):562-70. PMID 21177394.

5. Zivadinov R, Galleotti R, Hojnacki D, Menegatti E, Dwyer MG, Schirda C, Malagoni AM, Marr K, Kennedy C, Bartolomei I, Magnano C, Salvi F, Weinstock-Guttman B, Zamboni P. Value of magnetic resonance venography for detection of internal jugular vein anomalies in multiple sclerosis. A pilot longitudinal study. AJNR Am J Neuroradiol 2011 May;32(5):938-46 PMID 21474626.

6. Zivadinov R, Brown MH, Schirda CV, Poloni GU, Bergsland N, Magnano CR, Durfee J, Kennedy C, Carl E, Hagemeier J, Benedict RH, Weinstock-Guttman B, Dwyer MG. Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis A case-control study. Neuroimage. 2012 Jan 2;59(1):331-9. Epub 2011 Jul 27. PMID 21820063.

7. Zivadinov R, Poloni GU, Marr K, Schirda CV, Magnano CR, Carl E, Bergsland N, Hojnacki D, Kennedy C, Beggs CB, Dwyer MG, Weinstock-Guttman B. Decreased brain venous vasculature visibility on susceptibility-weighted imaging venography in patients with multiple sclerosis is related to chronic cerebrospinal venous insufficiency. BMC Neurol. 2011 Oct 19;11:128. PMID: 22011402.

8. Magnano C, Schirda C, Weinstock-Guttman B, Wack DS, Lindzen E, Hojnacki D, Bergsland N, Kennedy C, Belov P, Dwyer MG, Poloni GU, Beggs CB, Zivadinov R. Cine cerebrospinal fluid imaging in multiple sclerosis. J Magn Reson Imaging. 2012 Jun 25. PMID: 22733409

9. Wack DS, Cox JL, Schirda CV, Magnano CR, Sussman JE, Henderson D, Burkard RF. Functional anatomy of the masking level difference, an FMRI study. PLoS One. 2012;7(7) Jul 27. PMID: 22848453

10. Zheng H, Zhao T, Qian Y, Schirda C, Ibrahim TS, Boada FE, Multi-Slice Parallel Transmission Three-Dimensional Tailored RF (PTX 3DTRF) Pulse Design for Signal Recovery in Ultra High Field Functional MRI. Journal of Magnetic Resonance 2013. PMID: 23348046.

11. Deng W, Boada F, Poser BA, Schirda C, Stenger VA. Iterative projection onto convex sets for quantitative susceptibility mapping. Magn Reson Med. 2014 Mar 6 PMID 24604410.

12. Stan AD, Schirda CV, Bertocci MA, Bebko GM, Kronhaus DM, Aslam HA, LaBarbara EJ, Tanase C, Lockovich JC, Pollock MH, Stiffler RS, Phillips ML. Glutamate and GABA contributions to medial prefrontal cortical activity to emotion: implications for mood disorders. Psychiatry Res. 2014 Sep 30 PMID 24973815.

13. Ahrens ET, Helfer BM, O'Hanlon CF, Schirda C., Clinical cell therapy imaging using a perfluorocarbon tracer and fluorine-19 MRI. Magn Reson Med. 2014 Sep 19 PMID 25241945.

14. Prasad KM, Upton CH, Schirda C, Nimgaonkar VL, Keshavan MS. White matter diffusivity and microarchitecture among schizophrenia subjects and first-degree relatives. Schizophr Res. 2014 Oct 30. PMID 25454798.

15. Schirda C., Zhao T., Andronesi OC, Lee Y., Pan, JW, Mountz JM, Hetherington HP and Boada, F, In vivo brain rosette spectroscopic imaging (RSI) with LASER excitation, constant gradient strength readout, and automated LCModel quantification for all voxels. Magnetic Resonance in Medicine, 2015 Aug 26, PMID 26308482.
Honors and  
PubMed Publications   See a listing of publications on PubMed, a service of the National Library of medicine.