Profile Detail

Vincent Schmithorst, PhD

Assistant Professor
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Interest (in 3 to 10 words):

Education
	9/84 8/89University of Cincinnati, Cincinnati, OH Bachelor of Science, 1989Physics Bachelor of Music, 1989Piano
Medical / Graduate School	9/92 8/97University of Cincinnati, Cincinnati, OH Master of Science, 1994Physics Doctor of Philosophy, 1997Physics
Residency
Clinical / Post-doctoral Fellowship	1997 2002Childrens Hospital, Cincinnati, OH Post-Doctoral Research Associate
Current	International Society for Magnetic Resonance in Medicine (2002 Present) Organization for Human Brain Mapping (2007 Present)
Specialties & Programs	MR Clinical Pre-clinical Translational
Clinical Interest	Neuro MRI
Research Interest	Functional MRI of hearing-impaired pediatric subjects. I have developed silent fMRI techniques suitable for use in the hearing-impaired pediatric population. I am interested in using them to investigate cortical reorganization following unilateral hearing loss, as well as the suitability of fMRI as a preoperative indicator for cochlear implantation in patients with severe-to-profound bilateral sensorineural hearing loss. Auditory Processing Disorder. I am interested in investigating the etiology and neurobiological underpinnings of APD in children using functional MRI. Current research suggests APD may in fact be more of a cognitive than a sensory disorder; if this is confirmed using neuroimaging techniques, this result will have profound implications for diagnosis and management strategies. White matter microstructure in the pediatric population. I am interested in investigating the normal development of white matter as well as its correlates with intelligence and other measures of cognitive function. Novel image analysis techniques for use on neuroimaging data. I have extensively utilized Independent Component Analysis (ICA), a data-driven method, as a complementary technique to conventional hypothesis-driven methods such as the General Linear Model (GLM) for analysis of fMRI data. I aim to use machine-learning techniques (multivariate pattern analysis) to enable functional MRI data (and other MRI data such as diffusion) to predict psychological and other pathologies, as well as outcomes.
Selected Publications	Schmithorst VJ, Holland SK, Plante E. Diffusion tensor imaging reveals white matter microstructure correlations with auditory processing ability. Ear Hear. 2011 Mar-Apr;32(2):156-67. PubMed PMID: 21063207; PubMed Central PMCID: PMC3057932. Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A linear structural equation model for covert verb generation based on independent component analysis of FMRI data from children and adolescents. Front Syst Neurosci. 2011;5:29. Epub 2011 Jun 1. PubMed PMID: 21660108; PubMed Central PMCID: PMC3106180. Propst EJ, Greinwald JH, Schmithorst V. Neuroanatomic differences in children with unilateral sensorineural hearing loss detected using functional magnetic resonance imaging. Arch Otolaryngol Head Neck Surg. 2010 Jan;136(1):22-6. PubMed PMID: 20083773. Schmithorst VJ. Developmental Sex Differences In The Relation Of Neuroanatomical Connectivity To Intelligence. Intelligence. 2009 Mar;37(2):164-173. PubMed PMID: 21297966; PubMed Central PMCID: PMC3032174. Schmithorst VJ. Higher-order contrast functions improve performance of independent component analysis of fMRI data. J Magn Reson Imaging. 2009 Jan;29(1):242-9. PubMed PMID: 19097110; PubMed Central PMCID: PMC2653629. Schmithorst VJ, Holland SK, Dardzinski BJ. Developmental differences in white matter architecture between boys and girls. Hum Brain Mapp. 2008 Jun;29(6):696-710. PubMed PMID: 17598163; PubMed Central PMCID: PMC2396458. Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med. 2008 Jan 10;358(2):140-51. PubMed PMID: 18184959. Schmithorst VJ, Holland SK, Plante E. Object identification and lexical/semantic access in children: a functional magnetic resonance imaging study of word-picture matching. Hum Brain Mapp. 2007 Oct;28(10):1060-74. PubMed PMID: 17133401; PubMed Central PMCID: PMC2763496. Schmithorst VJ, Holland SK, Plante E. Development of effective connectivity for narrative comprehension in children. Neuroreport. 2007 Sep 17;18(14):1411-5. PubMed PMID: 17712265; PubMed Central PMCID: PMC2762809. Schmithorst VJ, Holland SK. Sex differences in the development of neuroanatomical functional connectivity underlying intelligence found using Bayesian connectivity analysis. Neuroimage. 2007 Mar;35(1):406-19. Epub 2007 Jan 12. PubMed PMID: 17223578; PubMed Central PMCID: PMC2100392. Schmithorst VJ, Holland SK. Functional MRI evidence for disparate developmental processes underlying intelligence in boys and girls. Neuroimage. 2006 Jul 1;31(3):1366-79. Epub 2006 Mar 15. PubMed PMID: 16540350. Plante E, Holland SK, Schmithorst VJ. Prosodic processing by children: an fMRI study. Brain Lang. 2006 Jun;97(3):332-42. Epub 2006 Feb 7. PubMed PMID: 16460792; PubMed Central PMCID: PMC1463022. Schmithorst VJ, Holland SK, Plante E. Cognitive modules utilized for narrative comprehension in children: a functional magnetic resonance imaging study. Neuroimage. 2006 Jan 1;29(1):254-66. Epub 2005 Aug 18. PubMed PMID: 16109491; PubMed Central PMCID: PMC1357541. Schmithorst VJ, Wilke M, Dardzinski BJ, Holland SK. Cognitive functions correlate with white matter architecture in a normal pediatric population: a diffusion tensor MRI study. Hum Brain Mapp. 2005 Oct;26(2):139-47. PubMed PMID: 15858815; PubMed Central PMCID: PMC1859842. Schmithorst VJ, Holland SK, Ret J, Duggins A, Arjmand E, Greinwald J. Cortical reorganization in children with unilateral sensorineural hearing loss. Neuroreport. 2005 Apr 4;16(5):463-7. PubMed PMID: 15770152; PubMed Central PMCID: PMC1357558.
Honors and Awards
PubMed Publications	See a listing of publications on PubMed, a service of the National Library of medicine.