Profile Detail

Theodore Huppert, PhD

Associate Professor

Interest (in 3 to 10 words):

Medical / Graduate School MSc, Biophysics, Harvard University
PhD, Biophysics, Harvard University
Clinical / Post-doctoral Fellowship Biomedical Engineering, Dartmouth College
Current Society for Human Brain Mapping
Society of Photonics in Industry and Engineering
& Programs
Clinical Interest vestibular disorders
cerebral oxygen metabolism
neonatal HIE
Research Interest My lab works on the development of non-invasive optical imaging (NIRS) of the human brain. Our methods are applied to both adults and neonatal imaging.

Our current projects include optical imaging of brain function related to the control of balance and vestibular information, concussion, and urology. We also develop methods related to real-time brain imaging. My lab works with both optical and multimodal (fMRI, PET, and MEG) methods to understand the biophysics underlying brain activity and function.

Selected Publications   1.Grignon S, Forget K, Durand M, Huppert T. Increased left prefrontal activation during staring/mutism episodes in a patient with resistant catatonic schizophrenia: a near infrared spectroscopy study. Cogn Behav Neurol. Mar 2008;21(1):41-45.

2.Huppert TJ, Diamond SG, Boas DA. Direct estimation of evoked hemoglobin changes by multimodality fusion imaging. Journal of biomedical optics. Sep-Oct 2008;13(5):054031.

3.Huppert TJ, Allen MS, Diamond SG, Boas DA. Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model. Hum Brain Mapp. May 2009;30(5):1548-1567.

4.Abdelnour AF, Huppert T. Real-time imaging of human brain function by near-infrared spectroscopy using an adaptive general linear model. NeuroImage. May 15 2009;46(1):133-143.

5.Huppert TJ, Jones PB, Devor A, et al. Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia. Journal of biomedical optics. Jul-Aug 2009;14(4):044038.

6.Mesquita RC, Huppert TJ, Boas DA. Exploring neuro-vascular and neuro-metabolic coupling in rat somatosensory cortex. Physics in medicine and biology. Jan 21 2009;54(2):175-185.

7.Huppert TJ, Diamond SG, Franceschini MA, Boas DA. HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain. Applied optics. Apr 1 2009;48(10):D280-298.

8.Abdelnour F, Schmidt B, Huppert TJ. Topographic localization of brain activation in diffuse optical imaging using spherical wavelets. Physics in medicine and biology. Oct 21 2009;54(20):6383-6413.

9.Sevy AB, Bortfeld H, Huppert TJ, Beauchamp MS, Tonini RE, Oghalai JS. Neuroimaging with near-infrared spectroscopy demonstrates speech-evoked activity in the auditory cortex of deaf children following cochlear implantation. Hear Res. 2010 Dec 1;270(1-2):39-47

10.Abdelnour F, and Huppert TJ. A random-effects model for group-level analysis of diffuse optical brain imaging. Biomedical Optics Express, Vol. 2, Issue 1, pp. 1-25 (2011)

11.Abdelnour F, Genevese C and Huppert TJ. Hierarchical Bayesian regularization of reconstructions for diffuse optical tomography using multiple priors Biomedical Optics Express, Vol. 1, Issue 4, pp. 1084-1103 (2010)

12.Ycel MA, Huppert TJ, Boas DA, Gagnon L. Calibrating the BOLD signal during a motor task using an extended fusion model incorporating DOT, BOLD and ASL data. Neuroimage. 2012 Apr 23;61(4):1268-1276. PMID: 22546318.

13.Karim H, Schmidt B, Dart D, Beluk N, Huppert T. Functional near-infrared spectroscopy (fNIRS) of brain function during active balancing using a video game system. Gait Posture. 2012 Mar;35(3):367-72. PubMed PMID: 22078300

14.Gagnon L, Ycel MA, Dehaes M, Cooper RJ, Perdue KL, Selb J, Huppert TJ, Hoge RD, Boas DA. Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements. Neuroimage. 2012 Feb 15;59(4):3933-40. PMID: 22036999

15.Huppert TJ, Beluk N, Schmidt BT, Furman J, Sparto S. Measurement of brain activation during an upright stepping reaction task using functional near-infrared spectroscopy (fNIRS). Human Brain Mapping.
Honors and  
PubMed Publications   See a listing of publications on PubMed, a service of the National Library of medicine.