Profile Detail

Joseph Leader, PhD

Research Assistant Professor

Interest (in 3 to 10 words):

Education Pennsylvania State University, B.S., Biology, 1984

University of Pittsburgh, Ph.D., Bioengineering, 2000

Pennsylvania State University
Medical / Graduate School MS, Bioengineering, University of Pittsburgh
PhD, Bioengineering, University of Pittsburgh
Clinical / Post-doctoral Fellowship
Current Institute of Electrical and Electronic Engineers
American Thoracic Society
& Programs
Digital Imaging
Clinical Interest
Research Interest Lung image analysis.

Development and validation of computer algorithms to improve quantitative assessment of structural changes of the lung depicted on CT examinations.

Investigate the association between pulmonary disease and structural changes of the lung for variety of diseases such as COPD, asthma, interstitial lung disease, and lung cancer.

Classify subjects based on structural changes of the lung that are responsible for functional abnormalities and predict the likelihood of rapid disease progression (i.e., risk).
Selected Publications   Leader JK, Zheng B, Rogers RM, Sciurba FC, Perez A, Chapman BE, Patel S, Fuhrman CR, and Gur D. Automated lung segmentation in x-ray computed tomography: development and evaluation of a heuristic threshold-based scheme. Acad Radiol, 2003, 10(11):1224-1236.

Leader JK, Warfel TE, Fuhrman CR, Golla SK, Weissfeld JL, Avila RS, Turner WD, Zheng B. Pulmonary nodule detection with low-dose CT of the lung: agreement among radiologists. AJR Am J Roentgenol, 2005, 185(4):973-978.

Gilbert S, Zheng B, Leader JK, Luketich JD, Fuhrman CR, Landreneau RJ, Gur D, Sciurba FC. Computerized estimation of the lung volume removed during lung volume reduction surgery. Acad Radiol, 2006, 13(11):1379-1386.

Zheng B, Leader JK, McMurray JM, Park SC, Fuhrman CR, Gur D, Sciurba FC. Automated detection and quantitative assessment of pulmonary airways depicted on CT images. Med Phys, 2007, 34(7):2844-2852.

Wilson DO, Weissfeld JL, Balkan A, Schragin JG, Fuhrman CR, Fisher SN, Wilson J, Leader JK, Siegfried J, Shapiro SD, Sciurba FC. Association of Radiographic Emphysema and Airflow Obstruction with Lung Cancer. Am J Respir Crit Care Med, 2008, 178(7):738-744. PMCID: PMC2556456.

Pu J, Leader JK, Zheng B, Knollmann F, Fuhrman C, Sciurba FC, Gur D. A computational geometry approach to automated pulmonary fissure segmentation in CT examinations. IEEE Trans Med Imaging, 2009, 28(5):710:719. PMCID: PMC2839918.

Pu J, Zheng B, Leader JK, Fuhrman C, Knollmann F, Klym A, Gur D. Pulmonary Lobe Segmentation in CT examinations Using Implicit Surface Fitting. IEEE Trans Med Imaging, 2009, 28(12):1986-1996. PMCID: PMC2839920.

Bon JM, Leader JK, Weissfeld JL, Coxson HO, Zheng B, Branch RA, Kondragunta V, Lee JS, Zhang Y, Choi AM, Lokshin AE, Kaminski N, Gur D, Sciurba FC. The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease. PLoS One, 2009, 4(8):e6865. PMCID: PMC2730536.

Pu J, Fuhrman C, Durick J, Leader JK, Klym A, Sciurba FC, Gur D. Computerized assessment of pulmonary fissure integrity using high resolution CT. Med Phys, 2010, 37(9):4661-4672. PMCID: PMC2937051.

Bon J, Fuhrman CR, Weissfeld JL, Duncan SR, Branch RA, Chang CC, Zhang Y, Leader JK, Gur D, Greenspan SL, Sciurba FC. Radiographic Emphysema Predicts Low Bone Mineral Density in a Tobacco Exposed Cohort. Am J Respir Crit Care Med, 2011, 183(7):885-90. PMCID: PMC3086755.

Wilson DO, Leader JK, Fuhrman CR, Reilly JJ, Sciurba FC, Weissfeld JL. Quantitative Computed Tomography Analysis, Airflow Obstruction, and Lung Cancer in the Pittsburgh Lung Screening Study. J Thorac Oncol, 2011, 6(7):1200:1205. PMCID: PMC3157578.

Park, SC, Leader JK, Tan J, Lee GS, Kim SH, Na IS, Zheng B. Separation of left and right lungs using 3-dimensional information of sequential computed tomography images and a guided dynamic programming algorithm. J Comput Assist Tomogr, 2011, 35(2):280-289. PMCID: PMC3061932.

Park SC, Tan J, Wang X, Lederman D, Leader JK, Kim SH, Zheng B. Computer-aided detection of early interstitial lung diseases using low-dose CT images. Phys Med Biol, 2011, 56(4):1139-1153. PMCID: PMC3165025.

Chandra D, Stamm J, Palevsky P, Leader JK, Fuhrman CR, Zhang Y, Bon J, Duncan SR, Branch RA, Weissfeld J, Gur D, Gladwin MT, Sciurba FC. The relationship between pulmonary emphysema and decline in kidney function. Chest, 2012, in press, PMCID: in process.

Pu J, Leader JK, Meng X, Whiting B, Wilson D, Sciurba FC, Reilly JJ, Bigbee WL, Siegfried J, Gur D. Three-dimensional Airway Tree Architecture and Pulmonary Function. Acad Radiol, 2012, in press, PMCID: in process.
Honors and  
PubMed Publications   See a listing of publications on PubMed, a service of the National Library of medicine.