Profile Detail

N. Scott Mason, PhD

Research Associate Professor

Interest (in 3 to 10 words):

Medical / Graduate School PhD, Organic Chemistry, Vanderbilt University Nashville, TN
Clinical / Post-doctoral Fellowship
Current Academy of Molecular Imaging
American Chemical Society
Society of Nuclear Medicine
Society of Radiopharmaceutical Sciences
& Programs
Nuclear Medicine
Clinical Interest NONE
Research Interest Development of radiolabeled P.E.T. tracers for non-invasive imaging applications in neuroscience applications.

Specific areas of interest include AD imaging (Abeta plaque and tau agents) and neuroinflammation as well as the application of P.E.T. radiotracer development in developmental biology.

Development and application of microfluidic techniques to P.E.T. radiotracer development
Selected Publications   Mason NS, Klunk WE, Debnath M, Flatt N, Huang G, Shao L, Mathis CA Synthesis and evaluation of [18F]PIB analogs as Abeta plaque imaging agents J. Label. Cmpd. Radiopharm. 50: S87, 2007

Mathis CA, Lopresti B, Mason N, Price J, Flatt N, Bi W, Ziolko S, DeKosky S, Klunk W Comparison of the amyloid imaging agents [F-18]3-F-PIB and [C-11]PIB in Alzheimers disease and control subjects J. Nucl. Med. 48 (Supp.2): 56P, 2007

Narendran R, Mason NS, Frankle G, Carney JP, Lopresti BJ, Litschge M, Mathis CA, Mountz JM, Laymon CM Human biodistribution and dosimetry of the D2/3 agonist [11C]N-propylnorapomorphine (NPA) from Positron Emission Tomography NeuroImage (41):T132, 2008.

Frankle WG, Cho RY, Narendran R, Mason NS, Vora S, Litschge M, Price JC, Lewis DA, Mathis CA. Tiagabine Increases [11C]Flumazenil Binding in Cortical Brain Regions in Healthy Control Subjects. Neuropsychopharmacology, 2009; 34(3):624-633.

Narendran R, Frankle G, Mason NS, Laymon CM , Lopresti BJ, Price JC, Kendro S, Vora S, Litschge M, Mountz JM, Mathis CA. Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [11C]-N-propyl-norapomorphine:preliminary evaluation and reproducibility studies. Synapse 63(7):574-584, 2009.

Cohen AD, Ikonomovic MD, Abrahamson EE, Paljug WR, Dekosky ST, Lefterov IM, Koldamova RP, Shao L, Debnath ML, Mason NS, Mathis CA, Klunk WE. Anti-Amyloid Effects of Small Molecule Abeta-Binding Agents in PS1/APP Mice. Lett. Drug Des. Discov., 2009; 6(6):437.

Soloff PH, Price JC, Mason NS, Becker C, Meltzer CC. Gender, personality, and serotonin-2A receptor binding in healthy subjects. Psychiatry Res. 2010; 181(1):77-84.

Epperly MW, Lai SY, Kanai AJ, Mason N, Lopresti B, Dixon T, Franicola D, Niu Y, Wilson WR, Greenberger JS. Effectiveness of Combined Modality Radiotherapy of Prthotopic Human Squamous Cell Carcinomas in Nu/Nu Mice using Cetuximab, Tirapazamine and MnSOD-Plasmid Liposome Gene Therapy. In Vivo, 2010; 24:1-8.

Narendran R, Mason S, Laymon C, Lopresti B, Velasquez N, May M, Kendro S, Martinez D, Mathis C, Frankle G. A comparative evaluation of the dopamine D2/3 agaonist radiotracer [11C]NPA and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum. JPET, 2010; doi 10.1124/jpet.109.163501.

Hewitson L, Lopresti BJ, Stott C, Mason NS, Tomko J. Influence of pediatric vaccines on amygdale growth and ligand binding in rhesus macaque infants: A pilot study. Acta Neurobiol. Exp. 2010; 70:147-164.

Honors and  
PubMed Publications   See a listing of publications on PubMed, a service of the National Library of medicine.